On February 15th, radiation can cause DNA damage, which in turn can lead to cell death. A new study published by Chinese scientists on the 13th in the British journal Cell Death and Differentiation revealed the key mechanism by which STING (Interferon Gene Stimulating Factor) protein drives radiation-induced cell death by binding to the DNA damage response protein PARP1 to synthesize the product molecule PAR (Polyadenosine diphosphate ribose). Animal experiments have shown that blocking or inhibiting this pathway can reduce intestinal radiation damage in mice by 70% and increase survival rates by 5 times. This discovery provides a new strategy for preventing side effects of cancer radiotherapy and treating acute radiation injuries.
Scan code to share